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WWOX gene is associated with HDL cholesterol and triglyceride levels

DOI: 10.1186/1471-2350-11-148

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A quantitative association analysis performed in 801 individuals selected from the Spanish general population.For HDL levels, two regions of intron 8 display clustering of positive signals (p < 0.05) but none of them was associated in the haplotypic analysis (0.07 ≤ p ≤ 0.165). For TG levels not only intron 8 but also a 27 kb region spanning from the promoter region to intron 4 are associated in this study. For the TG/HDL genetic association analysis, positive signals are coincident with those of the isolated traits. Interestingly, haplotypic analysis at the 5' region showed that variation in this region modified both HDL and TG levels, especially the latter (p = 0.003).Our results suggest that WWOX is a QTL for both TG and HDL.Altered lipid profile is one of the major determinants of cardiovascular disease, which is the first cause of death in the developed countries. Unhealthy diet and low physical activity both contribute to the appearance of dyslipidemia, but blood lipid profile is also highly heritable. In addition to several mendelian forms of hyperlipemia and hypertriglyceridemia, dyslipidemia is commonly a complex disease or group of diseases with an estimated heritability ranging from 25 to 80% [1]. A recent study performed in 1,275 coronary artery disease patients derived from the Regensburg Myocardial Infarction Family Study has described heritabilities of 27-48% for HDL cholesterol and 21-44% for LDL cholesterol [2].The genetic variation in genes such as lipoprotein lipase (LPL), hepatic lipase (LIPC), the LDL receptor (LDLR), the ABCA1 transporter or diverse apolipoproteins, has been found to influence blood lipid levels [3-8]. Lately, the rapid spread of genome-wide association studies has allowed not only the confirmation of previously described associations, but also the identification of many quantitative trait loci (QTL) for lipid levels across the genome [9-15]. One of these loci has been recently reported for HDL [16] and involves the WW-domain-c


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