Introduction Occupational injuries are the leading cause of morbidity and mortality among workers. The aim of this study was to analyze the frequency of occupational injuries and health status of workers. Material and methods The examined group consisted of 3.750 workers with health disorders. The control group included 1.800 healthy workers. Both groups were similar in terms of many factors that could contribute to the occurrence of occupational injuries. The injury rates were calculated in both groups. Results Workers with psychomotor and sensorimotor disorders, neuroses, obstructive sleep apnea, arterial hypertension, diabetes mellitus, hearing, vascular and sight impairments have been frequently injured compared to workers with other diseases. Discussion Due to the belief that accidents and occupational injuries are preventable, it is an imperative to study those factors which are likely to contribute to occurrence of accidents. The contributing factors could be the physical and mental state of workers. Conclusion Occupational injuries are significantly more common in the examined group than in controls.