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Adenomatoid odontogenic tumor - hamartoma/cyst or true neoplasm; a Bcl-2 immunohistochemical analysis.

Keywords: Adenomatoid odontogenic tumor , jaw swelling , Bcl-2

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Abstract:

Objectives: Adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, characterized histologically by the formation of ductlike structures with amyloidlike deposits. Histogenesis of AOT is still uncertain and it is often considered as a hamartomatous lesion rather than a true neoplasm. Aim of this study was to analyse the usefulness of detecting important apoptosis in assessing the biological potential of lesion and analyze the expression of Bcl-2 in AOT. Methods and Material: Five formalin fixed paraffin embedded blocks of adenomatoid odontogenic tumor were included in the study and were analysed for Bcl-2 protein is characterized by its ability to inhibit apoptosis. Results;The immunoreactivity for Bcl-2 protein was present in most of the epithelial cells of AOTs. Four of the five AOTs had moderate positivity; one was poorly stained for IHC. Conclusions: adenomatoid odontogenic tumor behaves more aggressively than in most cases that rules out AOT is a cyst. The same activating mutation that causes adenomatoid odontogenic tumor also causes hybrid odontogenic tumors, which is a neoplasm. Thus, based on currently available evidence with the literature and the findings in the present study, it can be considered adenomatoid odontogenic tumor to be a true neoplasm rather than a hamartoma/cyst.

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