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Diabetes does not affect outcome in patients with Enterobacteriaceae bacteremia

DOI: 10.1186/1471-2334-9-94

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We reviewed the medical charts of 1112 patients who were treated at a community teaching hospital for Enterobacteriaceae bacteremia from January 1997 through June 2007. Factors associated with in-hospital mortality were analyzed by logistic regression analysis.Among the 1112 patients with Enterobacteriaceae bacteremia, 181 (16.3%) were diabetic patients; 90 patients (8.1%) died while in the hospital. Compared to non-diabetic patients, diabetic patients were older (75.4 ± 11.9 years vs. 70 ± 16.6 years, p < 0.001) and had more comorbidities. However, mortality among diabetic and non-diabetic patients was not different [7.2% vs. 8.2%, RR 1.13; 95% CI (0.67–1.9); p = 0.39]. In a multivariate analysis, the variables associated with in-hospital mortality were age, the origin of the bacteremia, and the presence of immunosuppression. Diabetes was not associated with outcome.In this cohort of patients with Enterobacteriaceae bacteremia, diabetes was not associated with a poorer prognosis.Enterobacteriaceae are the dominant causal agents of Gram-negative bacteremia and are a major cause of morbidity and mortality [1]. The prevalence of diabetes is increasing worldwide [2]; considering the predisposition of diabetes patients to Enterobacteriaceae bacteremia [3], the number of patients with both diabetes and bacteremia caused by Enterobacteriaceae is likely to increase as well. However, information about the effect of diabetes on the prognosis of patients with infections in general, and with Enterobacteriaceae bacteremia in particular, is limited. In addition, some data are contradictory [3-6]. It is significant to determine whether diabetes has a negative impact on the prognosis of Enterobacteriaceae bacteremia so this would support the convenience of a more aggressive approach for these patients. We performed a retrospective cohort study to identify possible correlations between diabetes and prognosis in patients with Enterobacteriaceae bacteremia.The Sierrallana Hospital is


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