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VALIDATED SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CEFTAZIDIME IN DRY POWDER FOR INJECTION

Keywords: Ceftazidime , Visible spectrophotometric method , Folin-Ciocalteu (FC) reagent , Sodium carbonate , Chromogen

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Abstract:

The present manuscript describes simple, sensitive, accurate, precise and economical visible spectrophotometric method for estimation of ceftazidime in pharmaceutical dosage form. Method is based on the reaction of ceftazidime with Folin-Ciocalteu (FC) reagent in presence of 10 % sodium carbonate solution, giving blue colour chromogen, which shows maximum absorbance at 752 nm against reagent blank. Beer’s law was obeyed in the concentration range of 2.5-50 μg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the dosage form excipients was found. The results of analysis have been validated statistically and by recovery studies.

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