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TREATMENT OF INFANTILE SPASMS; TETRACOSECTIDE OR VIGABATRIN? A COMPARATIVE STUDY

Keywords: Infantile spasms , Hypsarrhythmia , Vigabatrin , Tetracosectide

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Abstract:

Introduction:Infantile spasms (IS) is an age specific epileptic syndrome. Due to poorresponse of IS to conventional antiepileptic drugs, scientists are always onthe lookout for newer, more effective drugs to treat the condition.Materials & Methods:In this study, 50 infants with IS symptoms, aged between 2-24 months, wererandomly divided into two equal groups, each treated either with Vigabatrinor ACTH (long acting Tetracosectide); the results for clinical efficacy ofmedication and drug side effects were compared.Results:After the sixth week of treatment, in the Vigabatrin group, 28% completeremission and 40% reduction in seizure frequencies was seen, while in theTetracosectide group there were 40.9% complete remission and 45.5%reduction in seizure frequencies, showing no significant difference betweenthe clinical responses found in the two groups (P=0.44).Conclusion:Vigabatrin effeciacy is similar to Tetracosectide, but since it is impossible toevaluate visual field constriction, a probable irreversible side effect of Vigabatrin, It's better to use Tetracosectide for the first line in the treatment of IS .

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