Contemporary pig production requires high demand on breeding large number of animals/pigs in a relatively small space while attaining maximum productivity. Their productivity is related to their health and ever-growing concern about less use of antibiotics in pig production. Measures have been taken to prevent diseases rather than cure them. Biosecurity measures prevent entry of pathogens into farm and their transmission between buildings. There are many critical points that must be taken care of: location, workers, farm entrance, breeding progeny, semen, transport animals, food, dead animals, feces, waste water, DDD, biosecurity in buildings etc. Standardized rules of biosecurity on farms need to be strictly followed to maintain high production.