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Conservation of the three-dimensional structure in non-homologous or unrelated proteins

DOI: 10.1186/1479-7364-6-10

Keywords: 3D protein structure , Conserved motifs , Unrelated proteins

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In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.


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