Painless and Needle free Supersonic Injection Technologies

Drug delivery is defined as any formulation or device that improves therapeuticeffectiveness of a drug by controlling the rate, time and place of the compoundentering the body. These aspects have been important to pharmaceutical industry,so, it is an important part of the drug development process.In the drug delivery by injection to the body Needle phobia affects at least10% of the general population. Subcutaneous injections are used for many reasons,including immunizations, administration of medications such as insulin andheparin, and to provide local anesthesia, both for surgery and for intravenouscannulation.Various approaches are employed to alleviate the pain causedby intravenous cannulation. These include jet injectors use a propelling force,which can be metal springs, compressed air, carbon dioxide, or helium gas,to create pressure that is used to literally “shoot” drug, in liquid or powderedform, in to the skin, provides needle free and pain free delivery of traditionaland biotechnology drugs and vaccines and has application to diagnostics. Appropriatelyformulated fine particles of 1 to 70 μm diameter are accelerated to sufficientlyhigh velocities in a hand held device using the energy of a transiently supersonichelium gas jet so that they can painlessly enter tissue. So, these devicescause little to no pain, and are simple to use, convenient, and effective.As a result, drugs or vaccines delivered by this way could be more efficaciousthan those delivered by traditional parenteral routes. In this technique,the drug particles have suitable physical and chemical properties and arein a specific size range, these are explaining in later. The technology canbe applied to traditional small molecules, peptides, proteins or DNA, i.e.any pharmaceutical agent or vaccine that can be formulated in to solid particlesof the appropriate size distribution, mass and strength. This article willreview the complementary approaches to the needle free injection, liquid andpowdered based NFI, systems, powder characteristic, summarize the currentlyavailable NFI technologies by different companies and advantages of the NFIcompare to the other drug delivery system.