An Overview On Brain Targeting Drug Delivery System

Target delivery of drug molecules to brain is one of the most challenging research areas in pharmaceutical sciences. The blood-brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics,antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especiallyneuropeptides. Therefore, various strategies have been proposed to improve the delivery of different drugs to this tissue which includesliposomes, colloidal drug carriers, micelles,chimeric peptide technology, intranasal and olfactory route of administration andnano technology. This review deals in brief about the status of the BBB, different pathologies of brain like neurodegenerative,cerebrovascular and inflammatory diseases. The first part of this article aims to review the strategies developed to circumvent the BBB and deliver drugs into the brain. The use ofnano technology andliposomes are discussed which are crucial part of this article as mainly used to target various CNS disorders. The later part of this article contains future aspects of brain drug targeting