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A NEW PROTOCOL FOR THE SYNTHESIS OF 2-AMINOTHIOPHENES THROUGH THE GEWALD REACTION IN SOLVENT-FREE CONDITIONS. Ein neues Protokoll für den Synthese von 2-Aminothiophene DURCH DIE Gewald Reaktion in l sungsmittelfreien Bedingungen.

Keywords: 2-Aminothiophenes, Gewald reaction, Green chemistry, Solvent-free

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A new set of green conditions have been developed for the preparation of tetrasubstituted 2-aminothiophene derivatives through the Gewald reaction between the respective ketones, ethyl cyanoacetate and elemental sulfur in the presence of morpholine. The synthesis was carried out under solvent-free conditions by stirring components at room temperature.


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