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Heterocyclic Letters 2011

A NEW PROTOCOL FOR THE SYNTHESIS OF 2-AMINOTHIOPHENES THROUGH THE GEWALD REACTION IN SOLVENT-FREE CONDITIONS. Ein neues Protokoll für den Synthese von 2-Aminothiophene DURCH DIE Gewald Reaktion in l sungsmittelfreien Bedingungen.

Josué S.Bello Forero, Erika M. de Carvalho, Joel Jones Junior and Flavia M. da Silva

Keywords: 2-Aminothiophenes, Gewald reaction, Green chemistry, Solvent-free

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Abstract:

A new set of green conditions have been developed for the preparation of tetrasubstituted 2-aminothiophene derivatives through the Gewald reaction between the respective ketones, ethyl cyanoacetate and elemental sulfur in the presence of morpholine. The synthesis was carried out under solvent-free conditions by stirring components at room temperature.

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