The title compound, C60H88O4·4CHCl3·2H2O, is the alkylated product of 5,11,17,23-tetra-tert-butylcalixarene. It adopts a distorted cone conformation which leads to an open cavity. All the phenolic rings are tilted so that their tert-butyl groups are pitched away from the calix cavity. Two opposite aromatic rings are close to being perpendicular to one another [dihedral angle 85.0 (2)°], while the other pair of opposite rings is almost parallel [dihedral angle 8.1 (2)°], and adjacent phenolic rings are almost perpendicular [dihedral angles 82.4 (1) or 87.9 (1)°]. In the crystal, the water molecule and calixarene interact by way of O—H...O hydrogen bonds.