Background & Objective: Administrators have to pay attention to nurses as an important group among hospitals employees in order to have better patient outcomes. Recently, nurses' quality of work life is a new concept that attention to it can improve organizational efficiency. This research is to investigate the quality of work life of nurses at Tehran University of Medical Sciences Hospitals in 2005-2006.Methods & Materials: This is a cross-sectional study. The research was conducted among 349 nursing employees. Data were gathered using a questionnaire consisted of 30 elements of QWL. The respondents were asked to determine their overall quality of work life. Validity of the questionnaire was evaluated using content validity and reliability was determined using test-retest method. Statistical analysis was carried out using SPSS statistical software package.Results: The results showed that the majority of nurses were dissatisfied with environmental health and safety at work, monetary compensation and job welfare. There was significant correlation between the executive position of nurses, years of experience and their salary (P<0.05).Conclusion: The study findings showed that nurses had a poor quality of work life. This indicates that majority of employees are unsatisfied with the most aspects of their quality of work life.