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Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes

DOI: 10.1186/1475-2840-12-6

Keywords: Fibulin-1, Arterial stiffness, Cardiovascular disease, Kidney disease, Diabetes

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Abstract:

Plasma fibulin-1 was determined in subjects with chronic kidney disease (n?=?32; median age 62.5, inter-quartile range 51 – 73 years) and 60 age-matched control subjects. Among kidney disease patients serological biomarkers related to cardiovascular disease (fibrinogen, interleukin 6, C-reactive protein) were measured. Arterial applanation tonometry was used to determine central hemodynamic and arterial stiffness indices.We observed a positive correlation of fibulin-1 levels with age (r?=?0.38; p?=?0.033), glycated hemoglobin (r?=?0.80; p?=?0.003), creatinine (r?=?0.35; p?=?0.045), and fibrinogen (r?=?0.39; p?=?0.027). Glomerular filtration rate and fibulin-1 were inversely correlated (r?=??0.57; p?=?0.022). There was a positive correlation between fibulin-1 and central pulse pressure (r?=?0.44; p?=?0.011) and central augmentation pressure (r?=?0.55; p?=?0.001). In a multivariable regression model, diabetes, creatinine, fibrinogen and central augmentation pressure were independent predictors of plasma fibulin-1.Increased plasma fibulin-1 levels were associated with diabetes and impaired kidney function. Furthermore, fibulin-1 levels were associated with hemodynamic cardiovascular risk markers. Fibulin-1 is a candidate in the pathogenesis of cardiovascular disease observed in chronic kidney disease and diabetes.The extracellular matrix protein fibulin-1 is emerging as a new factor in cardiovascular disease. The plasma concentration of fibulin-1 is a predictor of all cause and cardiovascular mortality in patients with diabetes mellitus [1].Fibulin-1 belongs to a family of extracellular matrix (ECM) proteins with functional associations with elastic fibers and basement membranes. Fibulin-1 interacts with a number of ECM molecules, but whether it serves a structural role has not yet been established [2]. Fibulin-1 is expressed in embryonic and adult vascular smooth muscle cells (VSMC) [3,4]. In adult blood vessels fibulin-1 is deposited in the medial layers surrounding

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