Currently, there is an important consensus regarding the fact that regions have lost their attraction in terms of European studies. This leads us to the following paradox: while the metaphor “Europe of the Regions” that had such great resonance in the 1990s has become discredited, the degree of regional commitment with the EU has been constantly rising. Nowadays, the EU is enmeshed in a crisis that is not only of an economic and financial nature, but also a crisis of democracy. In this context, it seems appropriate to ‘recover’ this study on the role of regions in the European system of governance. This paper aims, on the one hand, to review the evolution of the role of regions in the European system of governance, and on the other, to explore the way in which this role has been dealt with in the European integration literature. Its ultimate goal is to understand what the future prospects are for regions within the integration process.