In the title compound, C19H11N3O2SClBr, the chromene ring system and the thiazole ring are each approximately planar, with maximum deviations of 0.033 (3) and 0.006 (3) , respectively. The molecule adopts an E configuration about the central C=N double bond. The central thiazole ring makes dihedral angles of 9.06 (14)° and 12.07 (11)° with the chloro-substituted phenyl ring and the chromene ring, respectively. The molecular structure features a short C—H...O contact, which generates an S(6) ring motif. The crystal structure is stabilized by intermolecular N—H...O hydrogen bonds, which link the molecules into chains along the b axis. π–π stacking interactions [centroid-centroid distance = 3.4813 (15) ] are also present.