Stroke is inflammatory disorder and homeostasis among inflammatory mediators play critical role to develop clot that choke to cerebral artery. Polymorphism in genes that involve directly in inflammatory process and homocysteine metabolism may be responsible for mild to moderate risk of Stroke. The purpose of the present study was to estimate the influence of polymorphism in genes involved in regulation of inflammatory process and homocysteine metabolism on stroke susceptibility. Some of the homocysteine metabolizing genes and some of the inflammatory genes have independently significant effect on stroke susceptibility. Polymorphic gene or genetic factor as a whole is risk factor for stroke and influence the disease, diagnosis, effect of medicine on patients as well as the other risk factors.