Butea monosperma belongs to the subfamily “Caesalpinioideae”, family “Fabaceae”. It grows throughout the south Asian peninsula. It is traditionally being used as various forms of medicine. Here we describe about the recent development in the studies of its various parts like leaves, stem bark, fruits, seeds, flowers and their extracts and active principles against various disorders like diabetes, cancer and helminthic infections. Moreover, the bioactivity of various parts for anti-inflammatory, antioxidant, anticonvulsant, anti-conceptive, antimicrobial, antiviral, osteogenic, osteoprotective and hepatoprotective properties have been discussed in details across various studies carried out in various experimental animal models, in vitro, ex vivo and clinical studies as well. This review provides adequate information to develop suitable therapeutics out of this plant parts.