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The role of the microenvironment in tumor immune surveillance

Keywords: Oral lichen planus , oral squamous cell carcinoma , proteomic voting , tumor microenvironment , T cell lineages , tumor immune surveillance

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Abstract:

The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O’Shea & Paul, 2010 ). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.

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