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One pot synthesis of 2-hydroxy pyrrolidine derivatives

Keywords: 2-Hydroxypyrrolidine , cerium(III)chloride heptahydrate , 2 , 3-dihydrofuran

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One pot reaction of various 2-amino-thiadiazoles or thiazoles and 2,3- dihydrofuran under mild condition in presence of CeCl 3.7H 2O as catalyst transformed the amino group of 2-amino-thiadiazoles or thiazoles into a medicinally important 2-hydroxy pyrrolidine ring system in good to excellent yields. The generality of the reaction was sufficiently investigated and demonstrated. The new reaction path way for this conversion was established by spectroscopic and analytical methods.


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