This paper examines determinants of labor force participation of married women in District Gujrat, Pakistan. Although in Pakistan women are participating in labor force but their proportion is very low. According to Labor force Survey 2009-10 female labor force contribution is 15.45% which is very low as compared to other South Asian Countries. In this study an attempt is made to find out the determinants which affect female labor force participation. The study was conducted with a sample of 301 married women by using stratified two stage cluster sampling method. Multilayer Perceptron Neural Network Model was used for analysis purpose. The study showed that literacy status, area of residence, family system, family size, husband’s education were most important determinants in predicting female labor force participation.