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Glycerin as alternative solvent for the synthesis of Thiazoles

Keywords: Bromo ketone , thiourea , urea , thiazole , catalyst-free , glycerin.

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Abstract:

A variety of α-bromoketones undergoes smooth condensation with thiourea/ thioamide compounds to afford the corresponding substituted thiazole derivatives in excellent yields. The condensation reactions were carried out in a recyclable reaction medium glycerin without using any catalyst. All the reactions were completed within 2 hours of reaction time at room temperature.

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