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HIGH LEVEL OF GST-P mRNA IN ISLAND TYPE OF RAT ASCITES HEPATOMA CELL LINES

Keywords: GST-P , Albumin , Ascites hepatoma , mRNA

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Abstract:

Several cell lines (18) of poorly differentiated rat ascites hepatomas which grown intraperitoneally were analyzed with respect to their mRNA levels of GST-P and albumin. The expression of albumin was dramatically decreased and became undetectable in all of the examined hepatomas compared with normal rat liver. The GST-P mRNA level in the hepatomas was correlated with their ability for formation of cellular islands in ascites. The island types, expressed GST-P at high level and the free type ones showed very low level of GST-P mRNA.

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