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The prevalence of hyperuricemia in China: a meta-analysis

DOI: 10.1186/1471-2458-11-832

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Epidemiological investigations on hyperuricemia in China published in journals were identified manually and on-line by using CBMDISC, Chongqing VIP database and CNKI database. Those Reported in English journals were identified using MEDLINE database. Selected studies had to describe an original study defined by strict screening and diagnostic criteria. The fixed effects model or random effects model was employed according to statistical test for homogeneity.Fifty-nine studies were selected, the statistical information of which was collected for systematic analysis. The results showed that the pooled prevalence of hyperuricemia in male was 21.6% (95%CI: 18.9%-24.6%), but it was only 8.6% (95%CI: 8.2%-10.2%) in female. It was found that thirty years was the risk point age in male and it was fifty years in female.The prevalence of hyperuricemia is different as the period of age and it increases after 30 years in male and 50 in female. Interventions are necessary to change the risk factors before the key age which is 30 years in male and 50 in female.Hyperuricemia (HU) is a result of multifactor interactions including gender, age, genetic and environmental factors. Classically, the following conditions are associated with HU: alcoholism, obesity, hypertension, dyslipidemia, hyperglycemia, diabetes mellitus, lithiasis, renal failure, and medication use (diuretics, cyclosporine, low-dose aspirin) [1]. In the past several decades, the prevalence varied greatly and appeared to be increasing. There was lots information that demonstrated the importance of serum uric acid to the clinical prognosis, so the importance of HU is increasing. It reported that 18.8% of the patients with HU developed into gout in a 5 year follow-up [2]. Independent association between HU and cardiovascular disease has been found in many studies [3,4]. Hyperuricemia has been reported to be associated with several components of metabolic syndrome (MetS) and authors have postulated that increased concent


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