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Microalbuminuria in relation to the metabolic syndrome and its components in a Chinese population

DOI: 10.1186/1758-5996-3-6

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Abstract:

The study subjects were recruited from a newly established residential area in the suburb of Shanghai. We measured anthropometry, blood pressure (BP), fasting plasma glucose, and serum lipids, and collected spot urine samples for the determination of albumin-creatinine ratio. We defined microalbuminuria as a urinary albumin-to-creatinine ratio of 30 to 299 mg/g. The metabolic syndrome was defined according to the International Diabetes Federation criteria.The 1079 participants included 410 (38.0%) hypertensive patients, and 66 (6.1%) diabetic patients. The prevalence of microalbuminuria (4.3%) was 3.2 times higher in 167 patients with the metabolic syndrome than 912 subjects without the metabolic syndrome (12.0% vs. 2.9%, P < 0.0001). In multiple regression adjusted for sex, age, body mass index, current smoking, alcohol intake and the use of antihypertensive drugs, and mutually adjusted for the components, microalbuminuria was significantly associated with diastolic BP (odds ratio 1.74 for +10 mmHg; 95% confidence interval [CI] 1.10-2.76; P = 0.02) and fasting plasma glucose (1.18; 95% CI 1.01-1.41; P = 0.04), but not with waist circumference, systolic BP, or serum HDL cholesterol and triglycerides (P > 0.10).Microalbuminuria is common in the Chinese population, and much more prevalent in the presence of the metabolic syndrome, mainly attributable to elevated diastolic BP and plasma glucose.Micoralbuminuria is an early marker of chronic kidney disease (CKD) [1] and vascular dysfunction [2], and is associated with a higher risk of renal function loss [1], cardiovascular events [1,3], and all-cause mortality [3]. Microalbuminuria is relatively common in patients with metabolic disorders, such as type 2 diabetes mellitus [4], and has been incorporated into the definition of the metabolic syndrome of the World Health Organization [5]. However, whether microalbuminuria should be an essential component of the metabolic syndrome remains controversial. Indeed, the Adult Tr

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