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Effects of IMOD? and Angipars? on mouse D-galactose-induced model of aging

DOI: 10.1186/2008-2231-20-68

Keywords: Aging, D-galactose, Oxidative stress, Cytokines, IMOD, Angipars, Animal

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Abstract:

Results showed that D-Galactose induces a significant oxidative stress and proinflammatory cascade of aging while both IMOD and Angipars recovered all of them. Interestingly, IMOD and Angipars were better than Vitamin E in improving male sex hormones in aged mice. This effect is so important and should be considered as an advantage although it cannot be explained with current knowledge. The conclusion is that IMOD and Angipars have marked anti-aging effect on D-galactose-induced model of aging.Use of natural medicines was increased in the world because of their lower adverse effects, price and good efficacy in most human illnesses [1-3]. Recent experimental and clinical studies have confirmed anti-aging effects of some traditionally-used herbs [4]. In the recent years, the novel registered drug named (IMOD) has shown positive effects on reduction of oxidative stress and pro-inflammatory status in various studies [5]. IMOD is a combination of ethanolic extracts of Rosa canina, Tanacetum vulgare and Urtica dioica that are combined with selenium and urea and then exposed to a pulsed electromagnetic field [6]. Angipars is also a registered drug derived from a plant named Melilotus officinalis under electromagnetic processes which has marked antioxidant effects and is used as a drug of choice for management of human diabetic foot [7,8]. Both IMOD and Angipars have been approved by Iranian Food and Drug Organisation for their main effects including human immunodeficiency syndrome and diabetic foot, respectively.Aging as an extremely complex biological phenomenon is demonstrated by accumulation of deleterious changes during the time with an increase in the chance of disease and death. The free radical and oxidative stress theory of aging is recognized as one of the most plausible and promising explanations for the process of aging [9]. Aging is associated with dysregulated immune system, weakened sex hormones and increased amount of oxidative stress markers or inflammatory

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