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Toxins  2010 

Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function

DOI: 10.3390/toxins2061179

Keywords: SPATE, autotransporters, pathogenic E. coli, Shigella,EspP, Pet, EspC, Sat, Vat, Hbp, EpeA, Pic, SepA, SigA, Tsh

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Abstract:

Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.

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