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Pharmaceutics  2012 

Trojan Microparticles for Drug Delivery

DOI: 10.3390/pharmaceutics4010001

Keywords: pharmaceutical nanotechnologies, microparticles, microspheres, vectors, solubility, permeability, dosage form, administration routes, drug targeting, release, nanoemulsion, trojan

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Abstract:

During the last decade, the US Food and Drug Administration (FDA) have regulated a wide range of products, (foods, cosmetics, drugs, devices, veterinary, and tobacco) which may utilize micro and nanotechnology or contain nanomaterials. Nanotechnology allows scientists to create, explore, and manipulate materials in nano-regime. Such materials have chemical, physical, and biological properties that are quite different from their bulk counterparts. For pharmaceutical applications and in order to improve their administration (oral, pulmonary and dermal), the nanocarriers can be spread into microparticles. These supramolecular associations can also modulate the kinetic releases of drugs entrapped in the nanoparticles. Different strategies to produce these hybrid particles and to optimize the release kinetics of encapsulated drugs are discussed in this review.

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