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Molecules  2012 

A New Iridoid Glycoside from the Roots of Dipsacus asper

DOI: 10.3390/molecules17021419

Keywords: Dipsacus asper, iridoid glycoside, loganic acid ethyl ester, neuroprotective effect, Dipsaceae

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Abstract:

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.

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