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Molecules  2009 

New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity

DOI: 10.3390/molecules14125382

Keywords: benzothiazole, N-oxides, push-pull systems, antibacterial, Euglena gracilis

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Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.


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