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Progress in Improving the Asymmetric Enantioselectivity of Lipase for Catalyzing Asymmetric Reaction

Keywords: lipase,enantioselectivity,asymmetric reaction

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Lipase has been extensively used in asymmetric reaction for producing optically pure compounds. Focused on improving the enantioselectivity of lipase for catalyzing asymmetric reaction, the recent researches have been summarized in this article, including reformation of lipase structure, reaction condition optimization, improvement of asymmetric reaction process and enantioselective inhibitation. Microwave irradiation can also be used to enhance the enantioselectivity of lipase in some level. Some traditional and new approaches, such as immobilization of enzyme, chemical modification, in vitro directed evolution, bio-imprinting, and optimization of reaction conditions were introduced.


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