In this paper we present the antimicrobial activity of some newly synthesized dibenz[ b, e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF 3) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF 3 and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.
Lazar, V; Balotescu, MC; Moldovan, L; Vasilescu, G; Petrache, LM; Bulai, D; Cernat, R. Comparative evaluation of qualitative and quantitative methods used in the study of antibacterial and antifungal activity of hydroalcoholic vegetal extracts. Roum. Biotechnol. Lett 2005, 10, 2225–2232.
Balotescu, MC; Oprea, E; Petrache, LM; Bleotu, C; Lazar, V. Antibacterial; antifungal and cytotoxic activity of Salvia officinalis essential oil and tinctures. Roum. Biotechnol. Lett 2005, 10, 2481–2481.