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Mercury Levels in an Urban Pregnant Population in Durham County, North Carolina

DOI: 10.3390/ijerph8030698

Keywords: mercury, fish consumption, pregnant women

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The adverse effects of prenatal mercury exposure, most commonly resulting from maternal fish consumption, have been detected at very low exposure levels. The omega-3 fatty acids found in fish, however, have been shown to support fetal brain and vision development. Using data from a prospective, cohort study of pregnant women from an inland area in the US South, we sought to understand the fish consumption habits and associated mercury levels across subpopulations. Over 30% of women had at least 1 μg/L of mercury in their blood, and about 2% had blood mercury levels above the level of concern during pregnancy (≥3.5 μg/L). Mercury levels were higher among Asian/Pacific Islander, older, higher educated, and married women. Fish consumption from any source was reported by 2/3 of the women in our study, with older women more likely to consume fish. Despite eating more fish meals per week, lower income, lower educated women had lower blood mercury levels than higher income, higher educated women. This suggests the different demographic groups consume different types of fish. Encouraging increased fish consumption while minimizing mercury exposure requires careful crafting of a complex health message.


[1]  Mercury Study Report to Congress, Volume VII: Characterization of Human and Wildlife Risks from Mercury Exposure in the United States. Report No: EPA-452/R-97-009; United States Environmental Protection Agency: Washington, DC, USA, 1997.
[2]  Committe on Nutrient Relationships in Seafood: Selections to Balance Benefits and Risks; Food and Nutrition Board. Seafood Choices: Balancing Benefits and Risks; The National Academies Press: Washington, DC, USA, 2006.
[3]  Oken, E; Wright, RO; Kleinman, KP; Bellinger, D; Amarasiriwardena, CJ; Hu, H; Rich-Edwards, JW; Gillman, MW. Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort. Environ. Health Perspect 2005, 113, 1376–1380.
[4]  Oken, E; Radesky, JS; Wright, RO; Bellinger, DC; Amarasiriwardena, CJ; Kleinman, KP; Hu, H; Gillman, MW. Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am. J. Epidemiol 2008, 167, 1171–1181.
[5]  Rogers, I; Emmett, P; Ness, A; Golding, J. Maternal fish intake in late pregnancy and the frequency of low birth weight and intrauterine growth retardation in a cohort of British infants. J. Epidemiolo. Community Health 2004, 58, 486–492.
[6]  Fredriksson, A; Dahlgren, L; Danielsson, B; Eriksson, P; Dencker, L; Archer, T. Behavioural effects of neonatal metallic mercury exposure in rats. Toxicology 1992, 74, 151–160.
[7]  Newland, MC; Warfvinge, K; Berlin, M. Behavioral consequences of in utero exposure to mercury vapor: Alterations in lever-press durations and learning in squirrel monkeys. Toxicol. Appl. Pharmacol 1996, 139, 374–386.
[8]  Grandjean, P; Budtz-Jorgensen, E; White, RF; Jorgensen, PJ; Weihe, P; Debes, F; Keiding, N. Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am. J. Epidemiol 1999, 150, 301–305.
[9]  Grandjean, P; White, RF; Nielsen, A; Cleary, D; de Oliveira Santos, E. Methylmercury Neurotoxicity in Amazonian Children Downstream from Gold Mining. Environ. Health Perspect 1999, 107, 587–591.
[10]  Grandjean, P; Weihe, P; Jorgenson, PJ; Clarkson, T; Cernichiari, E; Videro, T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch. Environ. Health 1992, 47, 185–196.
[11]  Jedrychowski, W; Jankowski, J; Flak, E; Skarupa, A; Mroz, E; Sochacka-Tatara, E; Lisowska-Miszczyk, I; Szpanowska-Wohn, A; Rauh, V; Skolicki, Z; Kaim, I; Perera, F. Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: Epidemiologic cohort study in Poland. Ann. Epidemiol 2006, 16, 439–447.
[12]  Lederman, SA; Jones, RL; Caldwell, KL; Rauh, V; Sheets, SE; Tang, D; Viswanathan, S; Becker, M; Stein, JL; Wang, RY; Perera, FP. Relation between cord blood mercury levels and early child development in a World Trade Center cohort. Environ. Health Perspect 2008, 116, 1085–1091.
[13]  Xue, F; Holzman, C; Rahbar, MH; Trosko, K; Fischer, L. Maternal fish consumption, mercury levels, and risk of preterm delivery. Environ. Health Perspect 2007, 115, 42–47.
[14]  Gale, TF; Ferm, VH. Embryopathic effects of mercuric salts. Life Sci. II 1971, 10, 1341–1347.
[15]  Olson, FC; Massaro, EJ. Effects of methyl mercury on murine fetal amino acid uptake, protein synthesis and palate closure. Teratology 1977, 16, 187–194.
[16]  Fuyuta, M; Fujimoto, T; Hirata, S. Embryotoxic effects of methylmercuric chloride administered to mice and rats during orangogenesis. Teratology 1978, 18, 353–366.
[17]  Rogers, I; Emmett, P; Ness, A; Golding, J. Maternal fish intake in late pregnancy and the frequency of low birth weight and intrauterine growth retardation in a cohort of British infants. J. Epidemiol. Community Health 2004, 58, 486–492.
[18]  Colombo, J; Kannass, KN; Shaddy, DJ; Kundurthi, S; Maikranz, JM; Anderson, CJ; Blaga, OM; Carlson, SE. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev 2004, 75, 1254–1267.
[19]  Dunstan, JA; Simmer, K; Dixon, G; Prescott, SL. Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: A randomised controlled trial. Arch. Dis. Child. Fetal Neonatal Ed 2008, 93, F45–F50.
[20]  Malcolm, CA; McCulloch, DL; Montgomery, C; Shepherd, A; Weaver, LT. Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. Arch. Dis. Child. Fetal Neonatal Ed 2003, 88, F383–F390.
[21]  Judge, MP; Harel, O; Lammi-Keefe, CJ. A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. Lipids 2007, 42, 117–122.
[22]  Helland, IB; Saugstad, OD; Smith, L; Saarem, K; Solvoll, K; Ganes, T; Drevon, CA. Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 2001, 108, E82.
[23]  Helland, IB; Smith, L; Blomen, B; Saarem, K; Saugstad, OD; Drevon, CA. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children’s IQ and body mass index at 7 years of age. Pediatrics 2008, 122, e472–e479.
[24]  Hightower, JM; O’Hare, A; Hernandez, GT. Blood mercury reporting in NHANES: Identifying Asian, Pacific Islander, Native American, and multiracial groups. Environ. Health Perspect 2006, 114, 173–175.
[25]  America’s Children and the Environment: Measures of Contaminants, Body Burdens, and Illnesses. Report No: EPA 240-R-03-001; United States Environmental Protection Agency, Office of Children’s Health Protection: Washington, DC, USA, 2003.
[26]  Bjornberg, KA; Vahter, M; Berglund, B; Niklasson, B; Blennow, M; Sandborgh-Englund, G. Transport of methylmercury and inorganic mercury to the fetus and breast-fed infant. Environ. Health Perspect 2005, 113, 1381–1385.
[27]  Mahaffey, KR; Clickner, RP; Bodurow, CC. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ. Health Perspect 2004, 112, 562–570.
[28]  Grandjean, P; Weihe, P; White, RF; Debes, F. Cognitive performance of children prenatally exposed to “safe” levels of methylmercury. Environ. Res 1998, 77, 165–172.
[29]  Mahaffey, KR; Clickner, RP; Jeffries, RA. Adult women’s blood mercury concentrations vary regionally in the United States: Association with patterns of fish consumption (NHANES 1999–2004). Environ. Health Perspect 2009, 117, 47–53.
[30]  Mayo Medical Laboratories. 2009–2010 Interpretive Handbook; Mayo Foundation for Medical Education and Research: Rochester, MN, USA, 2009.
[31]  Stern, AH; Gochfeld, M; Weisel, C; Burger, J. Mercury and methylmercury exposure in the New Jersey pregnant population. Arch. Environ. Health 2001, 56, 4–10.
[32]  Knobeloch, L; Anderson, HA; Imma, P; Peters, D; Smith, A. Fish consumption, advisory awareness, and hair mercury levels among women of childbearing age. Environ. Res 2005, 97, 220–227.
[33]  Caldwell, KL; Mortensen, ME; Jones, RL; Caudill, SP; Osterloh, JD. Total blood mercury concentrations in the U.S. population: 1999–2006. Int. J. Hyg. Environ. Health 2009, 212, 588–598.
[34]  Current Fish Consumption Advice and Advisories in North Carolina; North Carolina Division of Public Health: Raleigh, NC, USA, 2010.
[35]  Mercury Contamination in Fish: A Guide to Staying Healthy and Fighting Back; Natural Resources Defense Council: New York, NY, USA, 2010.
[36]  Fish 101; American Heart Association: Dallas, TX, USA, 2010.
[37]  Mahaffey, KR. Mercury exposure: medical and public health issues. Trans. Am. Clin. Climatol. Assoc 2005, 116, 127–153.
[38]  Rodier, PM. Developing Brain as a Target of Toxicity. Environ Health Perspect 1995, 103(Suppl 6), 73–76.


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