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AGRICOH: A Consortium of Agricultural Cohorts

DOI: 10.3390/ijerph8051341

Keywords: agriculture, cohort studies, consortium, pesticides, occupational exposures

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AGRICOH is a recently formed consortium of agricultural cohort studies involving 22 cohorts from nine countries in five continents: South Africa (1), Canada (3), Costa Rica (2), USA (6), Republic of Korea (1), New Zealand (2), Denmark (1), France (3) and Norway (3). The aim of AGRICOH, initiated by the US National Cancer Institute (NCI) and coordinated by the International Agency for Research on Cancer (IARC), is to promote and sustain collaboration and pooling of data to investigate the association between a wide range of agricultural exposures and a wide range of health outcomes, with a particular focus on associations that cannot easily be addressed in individual studies because of rare exposures (e.g., use of infrequently applied chemicals) or relatively rare outcomes (e.g., certain types of cancer, neurologic and auto-immune diseases). To facilitate future projects the need for data harmonization of selected variables is required and is underway. Altogether, AGRICOH provides excellent opportunities for studying cancer, respiratory, neurologic, and auto-immune diseases as well as reproductive and allergic disorders, injuries and overall mortality in association with a wide array of exposures, prominent among these the application of pesticides.


[1]  Blair, A; Zahm, SH; Pearce, NE; Heineman, EF; Fraumeni, JF, Jr. Clues to cancer etiology from studies of farmers. Scand. J. Work Environ. Health 1992, 18, 209–215.
[2]  Portengen, L; Sigsgaard, T; Omland, O; Hjort, C; Heederik, D; Doekes, G. Low prevalence of atopy in young danish farmers and farming students born and raised on a farm. Clin. Exp. Allergy 2002, 32, 247–253.
[3]  Douwes, J; Cheng, S; Travier, N; Cohet, C; Niesink, A; McKenzie, J; Cunningham, C; Le, GG; von Mutius, E; Pearce, N. Farm exposure in utero may protect against asthma, Hay fever and eczema. Eur. Respir. J 2008, 32, 603–611.
[4]  Greenlee, RT; Chyou, PH; Kieke, A; Naik, YG; Kirkhorn, S. Prevalence of asthma in a general population cohort of farm children: Comparison of estimates based on parental report and medical record review. J. Agromedicine 2008, 13, 225–231.
[5]  Pukkala, E; Martinsen, JI; Lynge, E; Gunnarsdottir, HK; Sparen, P; Tryggvadottir, L; Weiderpass, E; Kjaerheim, K. Occupation and cancer-follow-up of 15 million people in five Nordic countries. Acta. Oncol 2009, 48, 646–790.
[6]  Blair, A; Beane Freeman, L. Epidemiologic studies of cancer in agricultural populations: Observations and future directions. J. Agromedicine 2009, 14, 125–131.
[7]  Hoppin, JA; Umbach, DM; London, SJ; Alavanja, MC; Sandler, DP. Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmers. Am. J. Respir. Crit. Care Med 2004, 169, 1308–1313.
[8]  Schenker, MB; Farrar, JA; Mitchell, DC; Green, RS; Samuels, SJ; Lawson, RJ; McCurdy, SA. Agricultural dust exposure and respiratory symptoms among California farm operators. J. Occup. Environ. Med 2005, 47, 1157–1166.
[9]  Kamel, F; Engel, LS; Gladen, BC; Hoppin, JA; Alavanja, MC; Sandler, DP. Neurologic symptoms in licensed pesticide applicators in the agricultural health study. Hum. Exp. Toxicol 2007, 26, 243–250.
[10]  Nordby, KC; Andersen, A; Irgens, LM; Kristensen, P. Indicators of mancozeb exposure in relation to thyroid cancer and neural tube defects in farmers’ families. Scand. J. Work Environ. Health 2005, 31, 89–96.
[11]  Borugian, MJ; Robson, P; Fortier, I; Parker, L; McLaughlin, J; Knoppers, BM; Bedard, K; Gallagher, RP; Sinclair, S; Ferretti, V; et al. The Canadian partnership for tomorrow project: Building a pan-Canadian research platform for disease prevention. CMAJ 2010, 182, 1197–1201.
[12]  Olfert, SM; Pahwa, P; Dosman, JA. Longitudinal analysis of pulmonary dysfunction in the initial years of employment in the grain industry. J. Agric. Saf. Health 2005, 11, 415–422.
[13]  Pahwa, P; Senthilselvan, A; McDuffie, HH; Dosman, JA. Longitudinal decline in lung function measurements among Saskatchewan grain workers. Can. Respir. J 2003, 10, 135–141.
[14]  Wesseling, C; Ahlbom, A; Antich, D; Rodriguez, AC; Castro, R. Cancer in Banana plantation workers in Costa Rica. Int. J. Epidemiol 1996, 25, 1125–1131.
[15]  Romitti, PA; Watanabe-Galloway, S; Budelier, WT; Lynch, CF; Puzhankara, S; Wong-Gibbons, D; Hoppin, JA; Alavanja, MC. Identification of Iowa live births in the agricultural health study. Arch. Environ. Occup. Health 2010, 65, 154–162.
[16]  Merchant, JA; Stromquist, AM; Kelly, KM; Zwerling, C; Reynolds, SJ; Burmeister, LF. Chronic disease and injury in an agricultural county: The Keokuk county rural health cohort study. J. Rural. Health 2002, 18, 521–535.
[17]  Alavanja, MC; Sandler, DP; McMaster, SB; Zahm, SH; McDonnell, CJ; Lynch, CF; Pennybacker, M; Rothman, N; Dosemeci, M; Bond, AE; Blair, A. The agricultural health study. Environ. Health Perspect 1996, 104, 362–369.
[18]  Greenlee, RT; Zentner, J; Kieke, B, Jr; Elliott, J; Marlenga, B. Farm health surveillance in the Marshfield epidemiologic study area: A pilot study. J. Agric. Saf. Health 2005, 11, 211–218.
[19]  Yoo, KY; Shin, HR; Chang, SH; Lee, KS; Park, SK; Kang, D; Lee, DH. Korean multi-center cancer cohort study including a biological materials bank (KMCC-I). Asian Pac. J. Cancer Prev 2002, 3, 85–92.
[20]  Douwes, J; Travier, N; Huang, K; Cheng, S; McKenzie, J; Le, GG; von Mutius, E; Pearce, N. Lifelong farm exposure may strongly reduce the risk of asthma in adults. Allergy 2007, 62, 1158–1165.
[21]  Elholm, G; Omland, O; Schlunssen, V; Hjort, C; Basinas, I; Sigsgaard, T. The cohort of young Danish farmers—A longitudinal study of the health effects of farming exposure. Clin. Epidemiol 2010, 2, 45–50.
[22]  Hulin, M; Caillaud, D; Annesi-Maesano, I. Indoor air pollution and childhood asthma: Variations between urban and rural areas. Indoor Air 2010, 20, 502–514.
[23]  Baldi, I; Filleul, L; Mohammed-Brahim, B; Fabrigoule, C; Dartigues, JF; Schwall, S; Drevet, JP; Salamon, R; Brochard, P. Neuropsychologic effects of long-term exposure to pesticides: Results from the French phytoner Study. Environ. Health Perspect 2001, 109, 839–844.
[24]  Langseth, H; Gislefoss, RE; Martinsen, JI; Stornes, A; Lauritzen, M; Andersen, Aa; Jellum, E; Dillner, J. The Janus Serum Bank—From Sample Collection to Cancer Research; Cancer Registry of Norway: Oslo, Norway, 2009.
[25]  Kristensen, P; Andersen, A; Irgens, LM; Laake, P; Bye, AS. Incidence and risk factors of cancer among men and women in Norwegian Agriculture. Scand. J. Work Environ. Health 1996, 22, 14–26.
[26]  Melbostad, E; Venge, P; Danielsen, TA; Kjuus, H. Serum Eosinophil cationic protein in asthma of farmers. Scand. J. Clin. Lab Invest 2000, 60, 111–118.


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