Much research has been on the agro-divisions of the Huang-huai-hai Plain, but little quantitative study has ever been undertaken. This paper investigated 301 counties in the Huang-huai-hai Plain, and quantitatively and qualitatively probed the general strategic agro-divisions and layout of natural resources, crop output and gross agro-output values of the plain. The plain is primarily divided into low and high production areas. The high production areas are in turn divided into 7 micro-advantageous regions, which are advantageous regions of foodstuff; cotton; oil crops; foodstuff and cotton; foodstuff and oil crops; cotton and oil crops; and foodstuff, cotton and oil crops. On this basis, specific layouts are developed for each group. Such is of strategic and theoretical significance to agricultural development in the Huang-huai-hai Plain.