Considering the pile-soil-structure interaction (PSSI),the formula of the downwind displacement response is derived for highrise building subjected to fluctuating wind load. Numerical examples show that PSSI has evident effect on downwind displacement response of the building. Generally speaking,it is not always conservative to consider PSSI in the analysis of downwind responses of tall building. When the damping in the soil is small,the elastic relative displacement response of the structure considering the PSSI may be greater than that without considering the PSSI,and the total displacement response of the structure considering PSSI is always greater than that without considering PSSI,which may increase the uncomfortableness of the structure. This phenomenon becomes more significant if the building is higher. So more attention should be paid to the effect of the PSSI in the design of tall building.