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Mechanism of Affective and Cognitive-Control Brain Regions in Depression

Keywords: affective processing,cognitive control,interaction,depression

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Depression is characterized by a negativity bias which is a stable factor of it. The bias reflects enhanced bottom-up responses to affective stimuli,linked to deficits in amygdala and fusiform gyrus function. Alternatively,the bias also reflects impaired top-down cognitive control,linked to deficits in dorsolateral prefrontal cortex and anterior cingulate function. A new hypothesis that the occurrence of depression is caused by interaction of increased activity in affective brain regions and deficits in cog...


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