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Application of Element and Metablism Balancing for the Cultivation Process with Streptomyces aureofaciens
元素衡算和代谢衡算在金色链霉菌培养过程的应用研究

Keywords: element balancing and metablism balancing,Streptomyces aureofaciens,Chlorotetracycline,fermentation
元素衡算和代谢衡算,
,金色链霉菌,,金霉素,,发酵

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Abstract:

On the base of element and metablism balancing, the mathematical model of the cultivation process with Streptomyces aureofaciens was developed, and the unknown parameters in the model were estimated with the method of nonlinear optimization. Firstly the energetic coefficient of CTC biosynthesis was gained, which was 1.8 - 2.8 mol-ATP x C-mol(-1). The macroscopic reaction rates were predicted in the process and compared with the experimental values. The results show that the model can preferably describe the relationships between several macroscopic reaction rates in the process and can supervise the optimization of CTC fermentation process theoretically.

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