A study to estimate the economic impact of an eradication program for a brucellosis outbreak was performed in a dairy herd in the Mexicali Valley in Mexico. The study was done in a dairy herd with 175 Holstein Friesian cows. The presence of Brucella abortus was confirmed by bacteriological analysis done on milk samples obtained from positive animals. The impact was estimated by comparing economic costs and losses. The costs and income related with the control program were considered and used to determine the economic impact by means of a partial budget analysis. The result of the analysis indicated that the use of the government recommended program had excessively high costs which made the program economically unfeasible. Taking into account that the highest loss was as a result of the reduction of milk production because of the cows culled from the herd, it was considered that to make the program attractive to other milk producers, the government should establish a subsidy that paid for the cattle that was slaughter because in the case of the milk farm considered in this study with this payment, plus the income obtained from the sell of the positive cattle the amount of money obtained helped to reduce in 87.6% the total loss associated to the eradication program.