The purpose of this study was to develop a web-based instruction blended learning design to demonstrate an undergraduate student s performance on a 80/80 basis to determine the effectiveness index of the web-based instruction blended learning on the development of undergraduate students to compare the academic achievement of students between their performance both before and after the test and finally to study the satisfaction and improvement of the students towards learning lessons on the web. The sample that was used for this study was one group of 30 undergraduate students majoring in New Media at the Faculty of Informatics, Mahasarakham University. The 30 students were selected using a purposive sampling technique from the students basic design semester 2 academic year 2010. The materials used in this study were web-based instruction blended learning achievement tests and satisfaction questionnaires. The statistics were used to analyze data including finding an average and standard deviation. The test (t-test dependent) results showed that lessons on the internet combined with process optimization represented 87.52% and effective results represented 85.23% which indicates that a combination of web-based lessons were effective (E1/E2) at an index academic achievement score of 0.71, 87.52/85.23. The students were statistically significant at the 0.01 level and the students were highly satisfied with learning from lessons on the web. This study uses a lesson of web-based instruction blended learning to measure efficiency and effectiveness. Students were highly satisfied after learning from this lesson and it can be said that this technique can be used to teach students to achieve their goals independently.