The study found out the characteristics of females who studied mathematics-based courses in some universities in Uganda. The study adopted the descriptive survey design with simple percentages used in analysing the data. One validated instrument (FSMRCQ) was used in collecting data for the study. The subject of the study was made up of 1000 female students studying mathematics related courses in some universities in Uganda. Results showed that the parent/guardian background and occupation, perceptions of mathematics teachers (male and female), students interest and performance in secondary school mathematics predispose girls to study mathematics related courses as parents/guardians were interested in the performance of their wards in mathematics and that female students can perform as good as male students in sciences and mathematics. It was recommended that policy makers and government should take into consideration these characteristics in order to encourage females to enroll in mathematics related courses in higher institutions.