All Title Author
Keywords Abstract


NutriSim Diminishes an Endotoxin-stimulated Proinflammatory Cytokine Production

DOI: 10.5923/j.ajb.20120206.01

Keywords: Nutrisim , TNF-α, IL-1, IL-6, Endotoxic Shock, Lipopolysaccharide

Full-Text   Cite this paper   Add to My Lib

Abstract:

Lipopolysaccharide, a main component of Gram-negative bacterial endotoxin is the leading cause of sepsis or endotoxic shock. This condition generates tissue hypoperfusion and leads to a state of acute metabolic-circulatory dysfunction and multiorgan systemic failure which contributes to amplify the inflammatory response and resulting in the release of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6). The effect of NutriSim on serum pro-inflammatory cytokine concentrations were investigated in lipopolysaccharide-treated male Wistar rats. Animals were randomized into five groups: control groups receiving a single intraperitoneal injection of physiologic saline solution or NutriSim (10μl), respectively; LPS (20 mg/Kg, i.p.); NutriSim treatment 15 min before or after LPS in the same aforementioned dose. The results showed that a single dose of NutriSim prior or before the endotoxic insult diminishes significantly the production of serum TNF-α, IL-1 and IL-6. Therefore NutriSim can modulate an inflammatory response in experimental model of endotoxic shock.

Full-Text

comments powered by Disqus