In this work, anovel on-line process for pressurised hot organic solvent extraction of antioxidants from plantsas well as precipitation of the extract with or without a carrier material in one step was developed. This process has been called OEPO,Organic solvent Extraction and On-line particle formation. With this process, different products with a very low residual organic solvent concentration (< 50 ppm) can be obtained by the use of supercritical CO2 as anti solvent for solvent elimination.OEPO process consists of hyphenated Pressurized Liquid Extraction (PLE)-Supercritical Anti Solvent (SAS) precipitation, PLE-SAS co-precipitation and PLE-Supercritical Fluid Extraction of Emulsions (SFEE). OEPO process was successfully developed using Brazilian ginseng roots (Pfaffiaglomerata)as a model case using ethyl acetate as extracting solvent. Results were compared, in terms of antioxidant activity or morphology, with the ones obtained by each process separately.In addition, an optimization study for antioxidants recovery was performed using ethyl acetate as extracting solvent during PLE process. Optimum PLE extracts were produced under moderate extraction temperature (373 K) and high static extraction time (15 min). Under this condition an extraction yield of 1% (dry basis, d.b.) and an antioxidant activity of 53% are obtained, which was approximately 14% higherthan that observed after PLE-SAS precipitation and after SAS precipitation performed in two steps (step one - PLE extraction; step two – SAS precipitation by the use of the extract solution produced by step one stored).Similar behavior (hyphenated process producing similar products than the two step process done separately) was observed for PLE-SAS co-precipitation and PLE-SFEE indicating that the OEPO process developed in this work can be considered as a suitable and promising process to obtain, in only one step, different products (precipitated extract, co-precipitated extract or encapsulated extract in suspension), directly from plant materials.