Typhoid fever remains a major health problem in India and other developing countries. Antimicrobial resistance has sequentially emerged to number of drugs posing patient treatment challenges, that thus it has necessitated the search of formulated drugs for its treatments. Nitric oxide (NO) is a unique molecule produced in a biological system. Previous studies have suggested that exogenous administration of L-arginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. Considering these facts, it was thought pertinent to see the effect of oral administration of NO precursor i.e. L-Arginine. Formulation of NO precursor and ciprofloxacin are used in different concentration, which shows better therapeutic results against experimentally induced Salmonellosis.