This study was conducted to determine the suitability of packaging aspirin tablets in one thousand tablet packs that require reclosure after dispensing each dose. The reclosure efficiency of the push-fit type closure of a plastic container in preventing moisture entry was determined and compared to a control container. Aspirin tablets used in this study were shown to be susceptible to moisture degradation leading to significant losses of potency (p = 0.005). Loose placement of closure on container allowed significant gain of moisture into the container (p = 0.05) and this could lead to significant loss of potency of aspirin tablets. However, if the closure is properly pushed down to fit, the moisture gain is not significant (p = 0.05). It can, therefore, be concluded that the proper use of push-fit closures on containers for packaging aspirin tablets provides effective protection and the use of more expensive single unit strip packaging, for example, is therefore not necessary.