Background: Ganglion is one of the common lesions seen in minor surgical practice. Treatment of dorsal wrist ganglia varies from simple reassurance to excision and advanced endoscopic excision. Irrespective of the treatment modality, recurrence is a common problem. Materials and Methods: This study evaluates results of 40 wrist ganglia treated by using the transfixation technique. Results: Out of 40 cases included in this study 38 were completely cured of the symptoms giving a success rate of 95 percent, recurrence was seen in one patient and skin necrosis secondary to tight gauze piece was seen in one patient. Discussion: Comparing with other modalities this method is cost-effective, less time consuming, minimally invasive, low rate of recurrence, and can be carried out under local anesthesia, and does not require any special instrument and an easy-to-learn technique.