The Yezupil I archaeological loess site, situated in the East Carpathian Foreland (Ukraine), with two cultural layers (Middle and Upper Palaeolithic), has been systematically investigated by archaeologists and naturalists for about 20 years. These joint researches gave a very good basis for the palaeogeographical, cultural, and stratigraphic interpretation of the profile. The scope of the research included also TL analysis. The set of TL dates obtained formerly at the Lublin laboratory was supplemented with the dating results from the Gdańsk laboratory. Altogether, 28 samples were dated, enabling us to establish the chronostratigraphy of the profile. The obtained results correlate well with the European schemes of Pleistocene stratigraphy and Palaeolithic periodization. Additionally, finds connected with considerably younger (Holocene) settlement phases (Early Neolithic, Iron Age) in the Dniester River valley were dated.