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PLOS ONE  2008 

The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development

DOI: 10.1371/journal.pone.0002029

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Abstract:

Background Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes. Principal Findings We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. Significance Mych is a novel factor required for neural crest cell survival in zebrafish.

References

[1]  Dang CV (1999) c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1–11.
[2]  Grandori C, Cowley SM, James LP, Eisenman RN (2000) The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol 16: 653–699.
[3]  Oster SK, Marhin WW, Asker C, Facchini LM, Dion PA, et al. (2000) Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Mol Cell Biol 20: 6768–6778.
[4]  Secombe J, Pierce SB, Eisenman RN (2004) Myc: a weapon of mass destruction. Cell 16: 153–156.
[5]  Meyer N, Kim SS, Penn LZ (2006) The Oscar-worthy role of Myc in apoptosis Semin Cancer Biol 16: 275–287.
[6]  Ryan KM, Birnie GD (1996) Myc oncogenes: the enigmatic family. Biochem J 15: 713–721.
[7]  Lüscher B, Larsson LG (1999) The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation. Oncogene 13: 2955–2566.
[8]  Facchini LM, Chen S, Marhin WW, Lear JN, Penn LZ (1997) The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol. 17: 100–114.
[9]  Oster SK, Mao DYL, Kennedy J, Penn LZ (2003) Functional analysis of the N- terminal domain of the Myc oncoprotein. Oncogene 22: 1998–2010.
[10]  Barembaum M, Bronner-Fraser M (2005) Early steps in neural crest specification. Semin Cell Dev Biol 16: 642–646.
[11]  Bellmeyer A, Krase J, Lindgren J, LaBonne C (2003) The protooncogene c-myc is an essential regulator of neural crest formation in xenopus. Dev Cell 4: 827–839.
[12]  Light W, Vernon AE, Lasorella A, Iavarone A, LaBonne C (2005) Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells. Development 132(8): 1831–1841.
[13]  Wei K, Chen J, Akrami K, Galbraith GC, Lopez IA, et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45: 382–390.
[14]  Schreiber-Agus N, Horner J, Torres R, Chiu FC, DePinho RA (1993) Zebrafish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution. Mol Cell Biol 13: 2765–2775.
[15]  Loeb-Hennard C, Kremmer E, Bally-Cuif L (2005) Prominent transcription of zebrafish N-myc (nmyc1) in tectal and retinal growth zones during embryonic and early larval development. Gene Expr Patterns 5: 341–347.
[16]  Kudoh T, Tsang M, Hukriede NA, Chen X, Dedekian M, et al. (2001) A gene expression screen in zebrafish embryogenesis. Genome Res 11: 1979–1987.
[17]  Hukriede NA, Joly L, Tsang M, Miles J, Tellis P, et al. (1999) Radiation hybrid mapping of the zebrafish genome. Proc Natl Acad Sci USA 96: 9745–9750.
[18]  Kudoh T, Dawid IB (2001) Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Mech Dev 109: 95–98.
[19]  Kawahara A, Chien CB, Dawid IB (2002) The homeobox gene mbx is involved in eye and tectum development. Dev Biol 248: 107–117.
[20]  Thisse C, Thisse B, Halpern ME, Postlethwait JH (1994) Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev Biol 164: 420–429.
[21]  Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, et al. (2003) Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell 4: 67–82.
[22]  Odenthal J , Nüsslein-Volhard C (1998) Fork head domain genes in zebrafish. Dev Genes Evol 208: 245–258.
[23]  Akimenko MA, Ekker M, Wegner J, Lin W, Westerfield M (1994) Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J Neurosci 14: 3475–3486.
[24]  Chuang JC, Raymond PA (2002) Embryonic origin of the eyes in teleost fish. Bioessays 24: 519–529.
[25]  Phillips BT, Kwon HJ, Melton C, Houghtaling P, Fritz A, et al. (2006) Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol 294: 376–390.
[26]  Piotrowski T, Ahn DG, Schilling TF, Nair S, Ruvinsky I, et al. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development 2003 130: 5043–5052.
[27]  Lawson ND, Weinstein BM (2002) In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish. Dev Biol 248: 307–318.
[28]  Barrallo-Gimeno A, Holzschuh J, Driever W, Knapik EW (2004) Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development 131: 1463–1477.
[29]  O'Brien EK, d'Alen?on C, Bonde G, Li W, Schoenebeck J, et al. (2004) Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Dev Biol 265: 246–261.
[30]  Postlethwait JH, Yan YL, Gates MA, Horne S, Amores A, et al. (1998) Vertebrate genome evolution and the zebrafish gene map. Nat Genet 18: 345–349.
[31]  Westerfield M (1995) The zebrafish Book. The University of Oregon Press.
[32]  Hong SK, Haldin CE, Lawson ND, Weinstein BM, Dawid IB, et al. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci USA 102: 18473–18478.

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