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PLOS ONE  2012 

The Relation between Erythrocyte Trans Fat and Triglyceride, VLDL- and HDL-Cholesterol Concentrations Depends on Polyunsaturated Fat

DOI: 10.1371/journal.pone.0047430

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Abstract:

Background Trans fatty acids (TFA) lower HDL and increase triglyceride concentrations while polyunsaturated fatty acids (PUFA) lower triglycerides and may decrease HDL concentrations. The effect of the interaction between trans fat and PUFA on lipids is uncertain. Methods Men and women (n = 1032) in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) study were included. Fatty acids in erythrocyte membranes were measured with gas chromatography while data on potential confounders were obtained from questionnaires. To test the interaction between total erythrocyte PUFA (ePUFA) and TFA (eTFA) on lipid concentrations we distributed eTFA into tertiles and dichotomized ePUFA at the median concentration. Results For the 1st, 2nd and 3rd tertiles of eTFA, multivariate-adjusted means±s.e.m for HDL were 46.2±1.1, 46.3±1.1 and 45.5±1.0 mg/dL among those with low ePUFA, respectively, while they were 50.0±1.1, 46.9±1.1 and 44.7±1.1 mg/dL among those with high ePUFA, respectively (P for interaction = 0.01). For the 1st, 2nd and 3rd tertiles of eTFA, multivariate-adjusted means±s.e.m for triglycerides were 178.6±11.3, 144.7±10.9 and 140.8±10.6, respectively, among those with low ePUFA, while they were 133.8±11.3, 145.7±10.9 and 149.3±11.5, respectively, among those with high ePUFA (P for interaction = 0.005). Results for VLDL were similar to those for triglycerides. No significant interactions were observed for LDL or total cholesterol. Conclusions The relation between trans fat and HDL, VLDL and triglycerides may depend on PUFA. The benefit of avoiding trans fat may be greater among individuals with higher PUFA intake. Supplementation with PUFA among individuals with relatively high trans fat intake may have limited benefits on lipid profiles.

References

[1]  Hu FB, Manson JE, Willett WC (2001) Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 20: 5–19.
[2]  Sacks FM, Katan M (2002) Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med 113 Suppl 9B13S–24S.
[3]  Kabagambe E, Franklin FA (2010) Trans fatty acids, dyslipidemia and cardiovascular disease. In: Kwiterovich PO, editor. Johns Hopkins University Textbook of Dyslipidemia. 1 ed. Baltimore: Wolter Kluwer|Lippincott Williams and Wilkins. 238–244.
[4]  Khan S, Minihane AM, Talmud PJ, Wright JW, Murphy MC, et al. (2002) Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. J Lipid Res 43: 979–985.
[5]  Williams CM (1998) Dietary interventions affecting chylomicron and chylomicron remnant clearance. Atherosclerosis 141 Suppl 1S87–92.
[6]  Saravanan N, Haseeb A, Ehtesham NZ (2005) Ghafoorunissa (2005) Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. Eur J Endocrinol 153: 159–165.
[7]  Abbey M, Nestel PJ (1994) Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet. Atherosclerosis 106: 99–107.
[8]  Mozaffarian D, Pischon T, Hankinson SE, Rifai N, Joshipura K, et al. (2004) Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr 79: 606–612.
[9]  Tholstrup T, Raff M, Basu S, Nonboe P, Sejrsen K, et al. (2006) Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men. Am J Clin Nutr 83: 237–243.
[10]  Tholstrup T, Vessby B, Sandstrom B (2003) Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. Eur J Clin Nutr 57: 735–742.
[11]  Kabagambe EK, Baylin A, Siles X, Campos H (2003) Individual saturated fatty acids and nonfatal acute myocardial infarction in Costa Rica. Eur J Clin Nutr 57: 1447–1457.
[12]  Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, et al. (1999) Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 70: 1001–1008.
[13]  Noel SE, Newby PK, Ordovas JM, Tucker KL (2010) Adherence to an (n-3) Fatty Acid/Fish Intake Pattern Is Inversely Associated with Metabolic Syndrome among Puerto Rican Adults in the Greater Boston Area. J Nutr 140: 1846–1854.
[14]  Warensjo E, Sundstrom J, Lind L, Vessby B (2006) Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. Am J Clin Nutr 84: 442–448.
[15]  Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, et al. (2009) Smoking, inflammatory patterns and postprandial hypertriglyceridemia. Atherosclerosis 203: 633–639.
[16]  PROGENI (PROgram for GENetic Interaction). http://www.biostat.wustl.edu/progeni/(La?st accessed: September, 2012).
[17]  NCI (2007) Diet History Questionnaire, Version 1.0. National Institutes of Health, Applied Research Program, National Cancer Institute. http://riskfactor.cancer.gov/DHQ/(Last accessed: September, 2012).
[18]  Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, et al. (2001) Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires : the Eating at America’s Table Study. American Journal of Epidemiology 154: 1089–1099.
[19]  Thompson FE, Subar AF, Brown CC, Smith AF, Sharbaugh CO, et al. (2002) Cognitive research enhances accuracy of food frequency questionnaire reports: results of an experimental validation study. Journal of the American Dietetic Association 102: 212–225.
[20]  Corella D, Arnett DK, Tsai MY, Kabagambe EK, Peacock JM, et al. (2007) The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study. Clin Chem 53: 1144–1152.
[21]  Tsai MY, Hanson NQ, Straka RJ, Hoke TR, Ordovas JM, et al. (2005) Effect of influenza vaccine on markers of inflammation and lipid profile. J Lab Clin Med 145: 323–327.
[22]  Kabagambe EK, Tsai MY, Hopkins PN, Ordovas JM, Peacock JM, et al. (2008) Erythrocyte Fatty Acid Composition and the Metabolic Syndrome: A National Heart, Lung, and Blood Institute GOLDN Study. Clin Chem 54: 154–162.
[23]  Shen J, Arnett DK, Peacock JM, Parnell LD, Kraja AJ, et al. (2007) Interleukin 1-beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome. J Nutr 137: 1846–1851.
[24]  Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY (2006) Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem 52: 2265–2272.
[25]  Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H (2003) High 18:2 trans-fatty acids in adipose tissue are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults. J Nutr 133: 1186–1191.
[26]  Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC (2006) Trans fatty acids and cardiovascular disease. N Engl J Med 354: 1601–1613.
[27]  Kris-Etherton PM, Yu S (1997) Individual fatty acid effects on plasma lipids and lipoproteins: human studies. Am J Clin Nutr 65: 1628S–1644S.
[28]  Borba EF, Carvalho JF, Bonfa E (2006) Mechanisms of dyslipoproteinemias in systemic lupus erythematosus. Clin Dev Immunol 13: 203–208.

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