the aim of this study was to evaluate the quality of life and the presence of depressive symptoms among the caregivers and drug dependent people of the capsad. this is a cross-sectional study, with 109 users of four psychosocial care centers for alcohol and other drugs of mato grosso and their caregivers, using the instruments: medical outcomes studies 36 (sf-36), beck depression inventory (bdi) and a sociodemographic variables questionnaire. the qol of the caregivers in the domains functional capacity, physical aspect, pain and vitality were more affected when compared to the users. a strong correlation between qol and depressive symptoms was found in both groups. the comparisons performed demonstrate a compromise in the quality of life of both, with the group of caregivers most affected, confirming the situation of drug dependence as an important factor in the perception of the caregiver regarding their quality of life.